人腸癌組織
人乳腺癌組織
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技術服務完善的多組學（DNA\RNA\蛋白）檢測平臺
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空間多組學技術服務
技術背景
2022年空間多組學技術被Nature評為七大“顛覆性”技術之一，是將基因組、轉錄組、蛋白質組以及代謝組的檢測結果與組織原位信息相結合，重塑空間立體結構內相關組學信息的定位分布情況。隨著多個免疫治療藥物的獲批，腫瘤免疫療法日趨成熟，人們越來越多地關注組織微環境的概念及其在腫瘤免疫治療中的作用。腫瘤細胞可以通過釋放細胞外信號影響周邊的微環境，促進腫瘤血管增生和抑制周邊的免疫細胞，而腫瘤微環境中的免疫細胞及因子又可以影響腫瘤細胞的生長(見下圖)。
服務內容
空間多組學技術眾多，從高通量空間轉錄組和蛋白組到低通量RNA原位檢測技術和多重熒光免疫組化技術，不同方法學在各自應用領域發揮著獨特的作用。菲諾維康擁有完整的空間多組學平臺，集研發、實驗室服務以及臨床應用開發于一體，提供多組學（DNA\RNA\蛋白）一站式空間生物學解決方案。
應用方向
案例展示
空間表型分析可以將標記物組合（panel）分為幾大類：鑒別T細胞及其亞型（如殺傷性T細胞、輔助型T細胞）在腫瘤中的分布；鑒別M1型/M2型巨噬細胞在腫瘤中的分布；聚焦B細胞不同亞型（如CD20，CD21為代表的B細胞亞型）以及三級淋巴結構在腫瘤中的分布；關注更多種免疫細胞類型，如將NK細胞、樹突細胞引入到panel中，觀察不同免疫細胞在腫瘤中的分布；聚焦結合腫瘤標記物以及免疫檢測點，觀察不同幾大細胞類型（腫瘤細胞、B細胞、T細胞、巨噬細胞等）在腫瘤中的分布。
人黑色素瘤組織
人肺癌組織
參考文獻
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